I'm thinking it is a nutrient problem
Essential nutrient elements supplied by the soil but also through fertilization to complete adequate flow of nutrients for both macronutrients (required in large quantities such as N, P, K, Ca, Mg, S) and micronutrients (required in trace amounts such as B, Cu, Zn, Mn, Mo and Cl).Therefore, soil fertility evaluation is the necessary step to be carried out through TORITA to determine the suitable areas for tobacco production, covering both soil textures and nutritional status
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For example: A review of 214 studies published in 2020 in the Asian Pacific Journal of Cancer Prevention found that exposure to tobacco smoke was linked to a higher risk of breast cancer in women in Asia